Prairie View A&M vs. Lehigh odds, prediction: 2026 NCAA Tournament picks from proven model

The Prairie View A&M Panthers battle the Lehigh Mountain Hawks in a First Four matchup in the South regional of the NCAA Tournament on Wednesday night. The winner will be the 16th seed and will face the one-seeded Florida Gators on Friday. The Mountain Hawks (18-16) won the Patriot League Tournament last Wednesday, defeating Boston University 74-60, while the Panthers (18-17) won the SWAC Tournament, beating Southern 72-66 on Saturday. The Mountain Hawks have won eight of their last 10 games. The Panthers have won nine of their last 10 games. 

Tipoff from UD Arena in Dayton, Ohio, is set for 6:40 p.m. ET. Prairie View A&M will face Lehigh for the first time on Wednesday. Both teams are coming into the tournament having won five straight. Leigh is a 3.5-point favorite in the latest Prairie View A&M vs Leigh odds from DraftKings Sportsbook, while the over/under for total points scored is 142.5. 

Before making any Lehigh vs. Prairie View A&M picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 NCAA Tournament on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Prairie View A&M vs Lehigh 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits well over 50% of the time!